Dr. Marta Camilot from the University of Verona, Italy, discusses the challenges of setting up a cutoff for newborn screening. As examples, she addresses screening for two conditions: Congenital Hypothyroidism and Glucose-6-Phosphate Dehydrogenase Deficiency. “I want you to take home the message of playing with your cutoff. You have to calculate it, over and over again,“ she says. “Your mission is to identify potentially affected newborns, and the evaluation of your cutoff is the main tool.”