Migele™ Gel Electrophoresis Unit

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Detection of hemoglobinopathies in newborns

Migele™ Gel Electrophoresis Unit works with the RESOLVE™ hemoglobin kit to detect hemoglobinopathies in newborns and adults, including sickle cell disease and other hemoglobin variants and thalassemias. Now, blood screening labs all over the globe can conduct these crucial,lifesaving screenings with our easy-to-use, cost-efficient, scalable solution.

The unit works with a water bath and a power supply to run the IEF gel. The recirculating water bath stabilizes the temperature of the gel during the IEF process, while the programmable power supply provides high voltage to the electrophoresis unit. When the gel is positioned in the unit and an electrical current is applied to the gel, the hemoglobin variant possessing an individual isoelectric point (pI) migrates through the gel. When an individual variant’s pI equals the pH in the gel, it stops migrating and forms a discrete band. When all hemoglobin bands have been focused, the gel is fixed in trichloroacetic acid. To ensure band visibility, we recommend that newborn blood spot samples be stained with our JB-2 staining system.


Benefits Beyond Saving Lives

Outstanding Performance The IEF technique combined with the specially formulated gels results in excellent separation of differing hemoglobin bands, allowing you to achieve identifiable results.
Time Efficient The RESOLVE kit lets you to complete the run within 60 (small gel, FR-9120) to 90 (big gel, FR-9400, FR-9360) minutes, excluding sample preparation. Multiple electrophoresis units can be run at the same time to produce more results within the same time frame.
Scalable A typical setup includes two to four electrophoresis units on one circulating water bath. Expansion of the system is possible with minimal cost.
Flexible We offer you two different size gels; each size can be used on the electrophoresis unit to evaluate cord blood, blood spots, or whole blood samples from newborn and adult.
Multiple Evaluation Methods You can evaluate hemoglobin gels with or without stain. In newborn screening applications, staining is recommended. For this purpose, we offer the JB-2 staining system as well as trays and rocking systems to fix, rinse, and/or stain the gels.
Product may not be available in all countries. Please check availability with your local PerkinElmer representative
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Discovery in the details

Chemical Resistance:

The parts are resistant to solvents used in our kits. 

Maximum Gel Size:

240 × 203 mm (FR-9400, FR-9360) and 203 × 127 mm (FR-9120)

Cooling Plate Max

Pressure: 0.5 bar

Coolant Temperature:

+10 °C to +15 °C

Weight:

Approx. 12.5 kg

Electrical safety requirements:

• Safety standards EN 61010-1, 61010-2-101
• Maximum voltage: 2000 V
• Maximum power: 100 W

Dimensions:

351 mm x 520 mm x 125 mm-135 mm (W x L x H)


Achieve accurate results easily

The RESOLVE hemoglobin kit separates whole blood, cord blood, or dried blood spot specimen for detection of normal and variant hemoglobins by isoelectric focusing. The kit can run on a flatbed electrofocusing unit. This assay is intended for use as an aid in the diagnosis of neonatal and adult hemoglobinopathies. 


How it works

RESOLVE kits separate hemoglobins by IEF on a thin agarose gel. The clean separation of Hb F from Hb A permits differentiation of sickle cell anemia (Hb SS) from sickle cell trait (Hb AS). Due to the specificity and sensitivity of the gels we produce, separation of Hb C from Hb A2 and Hb E, as well as Hb D-Punjab and Hb G-Philadelphia from Hb S, is achieved. Hemoglobinopathies are clearly detected. The hemoglobin kit is available for both neonatal and adult testing.

For Hemoglobinopathies screening

Resolve™ Hemoglobin kit

The RESOLVE™ Systems Hemoglobin kit is designed to separate whole blood, cord bloodor dried blood spot specimen for detection of normal and variant hemoglobins byisoelectric focusing.The kit is designed to be run on a flat-bed electrofocusing unit.This assay is intended for use as an aid in the diagnosis of neonatal and adult hemoglobinopathies. - View kit

For Hemoglobinopathies screening

JB-2 Staining System

The JB-2 Staining System is designed to stain hemoglobin on RESOLVE Hemoglobinelectrophoresis gels (FR-9120, FR-9400, FR 9360). - View kit

For Hemoglobinopathies screening

ExtendSURE™ HbFASC Controls (Hb610)

In the detection of hemoglobin variants using gel electrophoresis, immunoassay or other technologies, HB610 extendSURE™ HbFASC controls provide the stability needed for reliable assay performance monitoring. - View kit

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